Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22510178 | 0.76 | HRH3 (0.55) | HTR1BHTR1ACHRNB4CHRNA3POLB | |
| SCHEMBL8793039 | 0.74 | CHRNB4 (0.49) | SLC6A4HTR2ACHRNB4CHRNA3EHMT2 | |
| SCHEMBL18475349 | 0.73 | TLR8 (0.51) | HTR2APOLB | |
| SCHEMBL8795585 | 0.72 | SLC6A4 (0.42) | SLC6A4HTR2AHTR1BHTR1ACHRNB4 | |
| SCHEMBL8794935 | 0.72 | CHRNB4 (0.49) | CHRNB4CHRNA3 | |
| SCHEMBL6740739 | 0.71 | HTR1B (0.51) | HTR2AHTR1BHTR1AHTR7HTR1D | |
| SCHEMBL27440375 | 0.71 | TLR8 (0.46) | HTR2APOLB | |
| SCHEMBL8705051 | 0.68 | CHRNB4 (0.60) | HTR2ACHRNB4CHRNA3 | |
| SCHEMBL11455709 | 0.68 | CHRNB4 (0.76) | HTR2ACHRNB4CHRNA3EHMT2 | |
| SCHEMBL11458219 | 0.68 | CHRNB4 (0.56) | CHRNB4CHRNA3EHMT2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0770079-A1 | HETEROBICYCLIC DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-05-02 | — | — | EP | disclosed |
| EP-0758330-A1 | BIPHENYLCARBOXAMIDES USEFUL AS 5-HT1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-02-19 | — | — | EP | disclosed |
| WO-1995030675-A1 | BIPHENYLCARBOXAMIDES USEFUL AS 5-HT1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-11-16 | — | — | WO | disclosed |