Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HTR1B | P28222 | 2/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KCNN2 | Q9H2S1 | 2/20 | 0.36 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.36 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8616789 | 0.81 | SLC6A4 (0.43) | SLC6A4HTR2AHTR7DRD1HRH2 | |
| SCHEMBL8614215 | 0.74 | HTR7 (0.44) | SLC6A4HTR2AHTR7ACHE | |
| SCHEMBL8617442 | 0.72 | CHRNB4 (0.46) | CHRNB4CHRNA3 | |
| SCHEMBL8792772 | 0.72 | SLC6A4 (0.47) | SLC6A4CHRNB4CHRNA3HTR2AHTR7 | |
| SCHEMBL8792100 | 0.72 | CHRNB4 (0.46) | CHRNB4CHRNA3 | |
| SCHEMBL8793039 | 0.72 | CHRNB4 (0.49) | SLC6A4CHRNB4CHRNA3HTR2AEHMT2 | |
| SCHEMBL8389362 | 0.70 | HTR2A (0.41) | SLC6A4HTR2AACHEHTR1BEHMT2 | |
| SCHEMBL5564105 | 0.69 | MAOA (0.49) | SLC6A4HTR2AHTR2CHTR2B | |
| SCHEMBL3953903 | 0.66 | HTR2A (0.40) | HTR2AACHEHTR1AEHMT2HTR2C | |
| SCHEMBL8393003 | 0.66 | NOS1 (0.40) | SLC6A4HTR2AACHEHTR1BEHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758330-A1 | BIPHENYLCARBOXAMIDES USEFUL AS 5-HT1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-02-19 | — | — | EP | disclosed |
| WO-1995030675-A1 | BIPHENYLCARBOXAMIDES USEFUL AS 5-HT1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-11-16 | — | — | WO | disclosed |