Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 18/20 | 0.69 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Israpafant SCHEMBL121587 | 1.00 | PTAFR (0.69) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| Israpafant SCHEMBL121588 | 1.00 | PTAFR (0.69) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| Israpafant SCHEMBL30733966 | 1.00 | PTAFR (0.69) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| Israpafant SCHEMBL8794591 | 0.99 | PTAFR (0.68) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| SCHEMBL9374585 | 0.92 | PTAFR (0.58) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| Israpafant SCHEMBL8792589 | 0.90 | PTAFR (0.57) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| SCHEMBL8878479 | 0.90 | PTAFR (0.67) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| SCHEMBL9374425 | 0.89 | PTAFR (0.64) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| SCHEMBL8877687 | 0.89 | PTAFR (0.57) | PTAFROPRK1PDE4DCYP3A4ALOX15 | |
| SCHEMBL8126816 | 0.89 | PTAFR (0.66) | PTAFROPRK1PDE4DCYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0480455-B1 | Optically active thienotriazolodiazepine compounds | YOSHITOMI PHARMACEUTICAL (JP) | 1997-01-22 | — | — | EP | claimed |
| JP-5086067-A | — | — | None | — | — | JP | disclosed |
| EP-0541407-B1 | Nitrogen containing bicyclic derivatives, method for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1997-02-26 | — | — | EP | disclosed |
| EP-0480455-B1 | Optically active thienotriazolodiazepine compounds | YOSHITOMI PHARMACEUTICAL (JP) | 1997-01-22 | — | — | EP | disclosed |
| US-5286858-A | Antagonist of platelet activating factor | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1994-02-15 | — | — | US | disclosed |
| JP-H0586067-A | OPTICALLY ACTIVE THIENOTRIAZOLODIAZEPINE COMPOUND | YOSHITOMI PHARMACEUT IND LTD | 1993-04-06 | — | — | JP | disclosed |
| EP-0480455-A1 | Optically active thienotriazolodiazepine compounds | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1992-04-15 | — | — | EP | disclosed |
| JP-H00586067-A | — | — | 0001-01-01 | — | — | JP | disclosed |