Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Israpafant. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 14/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Israpafant SCHEMBL121587 | 0.90 | PTAFR (0.69) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| Israpafant SCHEMBL8792967 | 0.90 | PTAFR (0.69) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| Israpafant SCHEMBL30733966 | 0.90 | PTAFR (0.69) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| Israpafant SCHEMBL121588 | 0.90 | PTAFR (0.69) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| Israpafant SCHEMBL8794591 | 0.90 | PTAFR (0.68) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL8879780 | 0.86 | PTAFR (0.57) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL9374585 | 0.84 | PTAFR (0.58) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL9374425 | 0.82 | PTAFR (0.64) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL9375379 | 0.82 | PTAFR (0.57) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL8126816 | 0.82 | PTAFR (0.66) | PTAFRCYP3A4ALOX15OPRK1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0480455-B1 | Optically active thienotriazolodiazepine compounds | YOSHITOMI PHARMACEUTICAL (JP) | 1997-01-22 | — | — | EP | claimed |
| US-5286858-A | Antagonist of platelet activating factor | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1994-02-15 | — | — | US | claimed |
| EP-0480455-A1 | Optically active thienotriazolodiazepine compounds | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1992-04-15 | — | — | EP | claimed |
| EP-0797576-A1 | ALKYL SUBSTITUTED PIPERADINYL AND PIPERAZINYL ANTI-AIDS COMPOUNDS | PHARMACIA & UPJOHN COMPANY (US) | 1997-10-01 | — | — | EP | disclosed |
| EP-0480455-B1 | Optically active thienotriazolodiazepine compounds | YOSHITOMI PHARMACEUTICAL (JP) | 1997-01-22 | — | — | EP | disclosed |
| US-5286858-A | Antagonist of platelet activating factor | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1994-02-15 | — | — | US | disclosed |
| EP-0480455-A1 | Optically active thienotriazolodiazepine compounds | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1992-04-15 | — | — | EP | disclosed |