Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 17/20 | 0.85 |
| ▸ | CA1 | P00915 | 3/20 | 0.57 |
| ▸ | CA12 | O43570 | 2/20 | 0.57 |
| ▸ | CA4 | P22748 | 2/20 | 0.57 |
| ▸ | CA6 | P23280 | 2/20 | 0.57 |
| ▸ | CA5A | P35218 | 2/20 | 0.57 |
| ▸ | CA7 | P43166 | 2/20 | 0.57 |
| ▸ | CA9 | Q16790 | 2/20 | 0.57 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.57 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | CA3 | P07451 | 1/20 | 0.57 |
| ▸ | AR | P10275 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8705272 | 1.00 | CA2 (0.85) | CA2CA1CA12CA4CA6 | |
| SCHEMBL8705268 | 1.00 | CA2 (0.85) | CA2CA1CA12CA4CA6 | |
| Hydrochloric Acid SCHEMBL9329594 | 0.99 | CA2 (0.84) | CA2CA1CA12CA4CA6 | |
| SCHEMBL8794650 | 0.96 | CA2 (0.79) | CA2CA1CA12CA4CA6 | |
| SCHEMBL8794424 | 0.94 | CA2 (0.76) | CA2CA1CA12CA4CA6 | |
| SCHEMBL8792791 | 0.92 | CA2 (1.00) | CA2CA1CA12CA4CA6 | |
| Hydrochloric Acid SCHEMBL9327510 | 0.91 | CA2 (0.98) | CA2CA1CA12CA4CA6 | |
| SCHEMBL8793668 | 0.90 | CA2 (0.69) | CA2CA1CA12CA4CA6 | |
| SCHEMBL8793403 | 0.89 | CA2 (0.67) | CA2CA1CA12CA4CA6 | |
| SCHEMBL8793532 | 0.89 | CA2 (0.68) | CA2CA1CA12CA4CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0452151-B1 | Substituted aromatic sulfonamides as antiglaucoma agents | MERCK & CO INC (US) | 1997-07-16 | — | — | EP | claimed |
| US-5308863-A | Carbonic anhydrase inhibitors | MERCK & CO., INC. (US) | 1994-05-03 | — | — | US | claimed |
| EP-0452151-A1 | Substituted aromatic sulfonamides as antiglaucoma agents | MERCK & CO. INC. (US) | 1991-10-16 | — | — | EP | claimed |
| EP-0576350-B1 | Branched alkylamino thiazole derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1997-10-29 | — | — | EP | disclosed |
| EP-0634401-B1 | MDR reversal agents | AMERICAN CYANAMID CO (US) | 1997-08-13 | — | — | EP | disclosed |
| EP-0452151-B1 | Substituted aromatic sulfonamides as antiglaucoma agents | MERCK & CO INC (US) | 1997-07-16 | — | — | EP | disclosed |
| US-5308863-A | Carbonic anhydrase inhibitors | MERCK & CO., INC. (US) | 1994-05-03 | — | — | US | disclosed |
| EP-0576350-A1 | Branched alkylamino thiozole derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1993-12-29 | — | — | EP | disclosed |
| EP-0452151-A1 | Substituted aromatic sulfonamides as antiglaucoma agents | MERCK & CO. INC. (US) | 1991-10-16 | — | — | EP | disclosed |