SCHEMBL879361

SCHEMBL879361

O=C(NC[C@H](NC(=O)c1c(Cl)cc2c(c1Cl)CCN(C(=O)c1ccc3ccoc3c1)C2)C(=O)O)c1cccs1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ITGB2 P05107 20/20 1.00
ICAM1 P05362 20/20 1.00
ITGAL P20701 20/20 1.00
CYP2C9 P11712 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16307478 1.00 ITGB2 (1.00) ITGB2ICAM1ITGALCYP2C9
SCHEMBL10129607 0.93 ITGB2 (0.90) ITGB2ICAM1ITGALCYP2C9
SCHEMBL19158058 0.92 ITGB2 (0.86) ITGB2ICAM1ITGALCYP2C9
SCHEMBL10168219 0.91 ITGB2 (0.83) ITGB2ICAM1ITGALCYP2C9
SCHEMBL13185744 0.90 ITGB2 (0.82) ITGB2ICAM1ITGALCYP2C9
SCHEMBL13167912 0.90 ITGB2 (0.82) ITGB2ICAM1ITGALCYP2C9
SCHEMBL13813604 0.90 ITGB2 (0.87) ITGB2ICAM1ITGAL
SCHEMBL4755821 0.90 ITGB2 (0.81) ITGB2ICAM1ITGALCYP2C9
SCHEMBL10129644 0.89 ITGB2 (1.00) ITGB2ICAM1ITGAL
SCHEMBL13658130 0.89 ITGB2 (0.80) ITGB2ICAM1ITGAL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-09-14 US disclosed
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-09-14 US disclosed
US-20230233551-A1 COMPOSITIONS AND METHODS FOR TREATMENT CITIBANK, N.A., AS NOTES COLLATERAL AGENT 2023-07-27 US disclosed
US-20230233551-A1 COMPOSITIONS AND METHODS FOR TREATMENT CITIBANK, N.A., AS NOTES COLLATERAL AGENT 2023-07-27 US disclosed
US-20230050819-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-02-16 US disclosed
US-20210338839-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF DIABETIC RETINOPATHY NOVARTIS AG (CH) 2021-11-04 US disclosed
US-20210283265-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-09-16 US disclosed
US-20210284629-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-09-16 US disclosed
US-20210238226-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-08-05 US disclosed
US-20210228723-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-07-29 US disclosed
US-20100093693-A1 MODULATORS OF CELLULAR ADHESION BAUSCH + LOMB IRELAND LIMITED (IE) 2010-04-15 US disclosed
US-20100093693-A1 MODULATORS OF CELLULAR ADHESION BAUSCH + LOMB IRELAND LIMITED (IE) 2010-04-15 US disclosed
US-20090155176-A1 Compositions and methods for treatment of diabetic retinopathy SARCODE CORPORATION (US) 2009-06-18 US disclosed
US-20090155176-A1 Compositions and methods for treatment of diabetic retinopathy SARCODE CORPORATION (US) 2009-06-18 US disclosed
US-20080182839-A1 MODULATORS OF CELLULAR ADHESION SUNESIS PHARMACEUTICALS, INC. (US) 2008-07-31 US disclosed
US-20080182839-A1 MODULATORS OF CELLULAR ADHESION SUNESIS PHARMACEUTICALS, INC. (US) 2008-07-31 US disclosed
US-20080176896-A1 Modulators of cellular adhesion BAUSCH + LOMB IRELAND LIMITED (IE) 2008-07-24 US disclosed
US-20080176896-A1 Modulators of cellular adhesion BAUSCH + LOMB IRELAND LIMITED (IE) 2008-07-24 US disclosed
US-7314938-B2 Immune and/or inflammatory disorders; autoimmune disorders; disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1); antagonize CD11/CD18 receptors associated with leukocytes. SUNESIS PHARMACEUTICALS, INC. (US) 2008-01-01 US disclosed
US-7314938-B2 Immune and/or inflammatory disorders; autoimmune disorders; disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1); antagonize CD11/CD18 receptors associated with leukocytes. SUNESIS PHARMACEUTICALS, INC. (US) 2008-01-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080176896-A1 Modulators of cellular adhesion ITGB1, VCAM1, ITGB8 ITGB2 8/4885ICAM1 5/4885ITGAL 11/4885
US-20210238226-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE ATXN2L, ATXN2, ATXN10 ITGB2 2851/4885ICAM1 4240/4885ITGAL 4225/4885
US-20090155176-A1 Compositions and methods for treatment of diabetic retinopathy VCAM1, ITGB1, ICAM1 ITGB2 11/4885ICAM1 3/4885ITGAL 5/4885
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, CBL, UBQLN2 ITGB2 4803/4885ICAM1 4630/4885ITGAL 4834/4885
US-20210283265-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, CBL, UBQLN2 ITGB2 4803/4885ICAM1 4630/4885ITGAL 4834/4885
US-20100093693-A1 MODULATORS OF CELLULAR ADHESION ITGB1, VCAM1, ITGB8 ITGB2 8/4885ICAM1 5/4885ITGAL 11/4885
US-20230050819-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE CYFIP2, TPX2, ATXN2 ITGB2 4235/4885ICAM1 4547/4885ITGAL 4839/4885
US-20230233551-A1 COMPOSITIONS AND METHODS FOR TREATMENT ICAM1, VCAM1, ITGAL ITGB2 8/4885ICAM1 1/4885ITGAL 3/4885
US-20210338839-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF DIABETIC RETINOPATHY VCAM1, ITGB1, ICAM1 ITGB2 11/4885ICAM1 3/4885ITGAL 5/4885
US-20210228723-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE ZFX, F13B, GRN ITGB2 2628/4885ICAM1 4275/4885ITGAL 3924/4885
US-20080182839-A1 MODULATORS OF CELLULAR ADHESION ITGB1, VCAM1, ITGB8 ITGB2 8/4885ICAM1 5/4885ITGAL 11/4885
US-20210284629-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, UBQLN2, UBTF ITGB2 4670/4885ICAM1 4564/4885ITGAL 4765/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.