Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9023031 | 0.86 | NAAA (0.48) | SIGMAR1ALDH1A1POLBMAPTHTR2A | |
| Hydrochloric Acid SCHEMBL6261405 | 0.84 | NAAA (0.47) | SIGMAR1CYP3A4ALOX15TSHRALDH1A1 | |
| SCHEMBL13884351 | 0.77 | SMN1; SMN2 (0.50) | SIGMAR1ALDH1A1LMNAOPRM1CASR | |
| SCHEMBL1118824 | 0.75 | MTOR (0.74) | SIGMAR1MTORRAB9AGRM7CYP3A4 | |
| SCHEMBL250445 | 0.74 | SMN1; SMN2 (0.40) | MTORRAB9AGRM7CYP3A4ALOX15 | |
| SCHEMBL12964248 | 0.74 | CYP3A4 (0.68) | SIGMAR1MTORRAB9AGRM7CYP3A4 | |
| SCHEMBL12964253 | 0.74 | CYP3A4 (0.68) | SIGMAR1MTORRAB9AGRM7CYP3A4 | |
| SCHEMBL172559 | 0.74 | CYP3A4 (0.68) | SIGMAR1MTORRAB9AGRM7CYP3A4 | |
| Hydrochloric Acid SCHEMBL565469 | 0.73 | SMN1; SMN2 (0.39) | MTORRAB9AGRM7CYP3A4ALOX15 | |
| SCHEMBL13884377 | 0.73 | HDAC4 (0.45) | MTORRAB9AGRM7CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0576350-B1 | Branched alkylamino thiazole derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1997-10-29 | — | — | EP | disclosed |
| CN-1035552-C | branched alkylamino derivatives of thiazoles, process for their preparation and pharmaceutical compositions containing them | SANOFI ELF (FR) | 1997-08-06 | — | — | CN | disclosed |
| US-5464847-A | Moduators of corticotropin releasing factor | ELF SANOFI (FR) | 1995-11-07 | — | — | US | disclosed |
| CN-1085898-A | branched alkylamino derivatives of thiazoles, process for their preparation and pharmaceutical compositions containing them | SANOFI ELF (FR) | 1994-04-27 | — | — | CN | disclosed |
| EP-0576350-A1 | Branched alkylamino thiozole derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1993-12-29 | — | — | EP | disclosed |