SCHEMBL8793755

SCHEMBL8793755

CCC(C)(C)Nc1cccnc1N1CCN(C(=O)c2cc3cc(N)ccc3[nH]2)CC1

nearest known ligand 0.55

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 1/20 0.55
ADORA3 P0DMS8 1/20 0.55
CHRM1 P11229 1/20 0.55
MAOA P21397 1/20 0.55
TBXA2R P21731 1/20 0.55
OPRM1 P35372 1/20 0.55
MDH1 P40925 1/20 0.55
KCNH2 Q12809 1/20 0.55
ABCG2 Q9UNQ0 1/20 0.55
HRH4 Q9H3N8 5/20 0.52
HRH3 Q9Y5N1 1/20 0.43
SYK P43405 3/20 0.42
KMT2A Q03164 2/20 0.41
MEN1 O00255 1/20 0.41
DRD2 P14416 1/20 0.41
DRD3 P35462 1/20 0.41
MAPT P10636 1/20 0.41
PARP1 P09874 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8924496 0.92 ADRA2A (0.58) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL8795199 0.87 HRH4 (0.55) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL8793814 0.86 ADRA2A (0.75) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL8795012 0.84 ADRA2A (0.74) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL8922916 0.82 ADRA2A (0.60) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL8794793 0.82 HRH4 (0.46) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9370616 0.80 HRH4 (0.55) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9369912 0.79 HRH4 (0.53) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL2818013 0.78 ADRA2A (0.58) ADRA2AADORA3CHRM1MAOATBXA2R
Atevirdine Mesylate SCHEMBL29365699 0.76 HRH4 (0.57) ADRA2AADORA3CHRM1MAOATBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993001181-A1 SUBSTITUTED INDOLES AS ANTI-AIDS PHARMACEUTICALS THE UPJOHN COMPANY (US) 1993-01-21 WO claimed
EP-0797576-A1 ALKYL SUBSTITUTED PIPERADINYL AND PIPERAZINYL ANTI-AIDS COMPOUNDS PHARMACIA & UPJOHN COMPANY (US) 1997-10-01 EP disclosed
US-5599930-A Substituted indoles as anti-AIDS pharmaceuticals THE UPJOHN COMPANY (US) 1997-02-04 US disclosed
EP-0594702-B1 SUBSTITUTED INDOLES AS ANTI-AIDS PHARMACEUTICALS UPJOHN CO (US) 1997-01-29 EP disclosed
EP-0594702-A1 SUBSTITUTED INDOLES AS ANTI-AIDS PHARMACEUTICALS. UPJOHN CO (US) 1994-05-04 EP disclosed
WO-1993001181-A1 SUBSTITUTED INDOLES AS ANTI-AIDS PHARMACEUTICALS THE UPJOHN COMPANY (US) 1993-01-21 WO disclosed