Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.58 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.58 |
| ▸ | MDH1 | P40925 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8793755 | 0.92 | ADRA2A (0.55) | ADRA2AADORA3CHRM1MAOATBXA2R | |
| SCHEMBL8795012 | 0.88 | ADRA2A (0.74) | ADRA2AADORA3CHRM1MAOATBXA2R | |
| SCHEMBL8922669 | 0.81 | KCNH2 (0.56) | ADRA2AADORA3CHRM1MAOATBXA2R | |
| SCHEMBL8923783 | 0.81 | GFER (0.42) | ADRA2AADORA3CHRM1MAOATBXA2R | |
| SCHEMBL9370616 | 0.80 | HRH4 (0.55) | ADRA2AADORA3CHRM1MAOATBXA2R | |
| SCHEMBL2818013 | 0.80 | ADRA2A (0.58) | ADRA2AADORA3CHRM1MAOATBXA2R | |
| SCHEMBL8795199 | 0.79 | HRH4 (0.55) | ADRA2AADORA3CHRM1MAOATBXA2R | |
| SCHEMBL9369912 | 0.79 | HRH4 (0.53) | ADRA2AADORA3CHRM1MAOATBXA2R | |
| SCHEMBL8793814 | 0.78 | ADRA2A (0.75) | ADRA2AADORA3CHRM1MAOATBXA2R | |
| SCHEMBL18326508 | 0.78 | ADRA2A (0.75) | ADRA2AADORA3CHRM1MAOATBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5599930-A | Substituted indoles as anti-AIDS pharmaceuticals | THE UPJOHN COMPANY (US) | 1997-02-04 | — | — | US | disclosed |