SCHEMBL8794012

SCHEMBL8794012

CCCC1(COC)CC(N)c2cc(S(=O)(=O)N=CN(C)C)sc2S1(=O)=O

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CA2 P00918 6/20 0.35
CA4 P22748 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8793243 0.89 CA2 (0.31) CA2
SCHEMBL8792668 0.87
Hydrochloric Acid SCHEMBL8793081 0.84 CA2 (0.47) CA2CA4
SCHEMBL8793313 0.74 CA2 (0.46) CA2CA4
Hydrochloric Acid SCHEMBL8793296 0.71 CA2 (0.56) CA2CA4
SCHEMBL9739506 0.67 CA2 (0.45) CA2CA4
SCHEMBL8791971 0.64 CA2 (0.44) CA2CA4
SCHEMBL23643377 0.63 CA2 (0.67) CA2CA4
SCHEMBL13435687 0.63 CA2 (0.67) CA2CA4
SCHEMBL23643348 0.63 CA2 (0.67) CA2CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0452151-B1 Substituted aromatic sulfonamides as antiglaucoma agents MERCK & CO INC (US) 1997-07-16 EP disclosed
US-5308863-A Carbonic anhydrase inhibitors MERCK & CO., INC. (US) 1994-05-03 US disclosed
EP-0452151-A1 Substituted aromatic sulfonamides as antiglaucoma agents MERCK & CO. INC. (US) 1991-10-16 EP disclosed