Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 18/20 | 0.45 |
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739170 | 0.88 | CA2 (0.36) | CA2CA1CA4CA12CA3 | |
| SCHEMBL9738834 | 0.84 | CA2 (0.34) | CA2CA1CA4CA12CA3 | |
| SCHEMBL23643348 | 0.71 | CA2 (0.67) | CA2CA1CA4CA12CA3 | |
| SCHEMBL13435687 | 0.71 | CA2 (0.67) | CA2CA1CA4CA12CA3 | |
| SCHEMBL23643377 | 0.71 | CA2 (0.67) | CA2CA1CA4CA12CA3 | |
| SCHEMBL9739006 | 0.70 | CA2 (0.52) | CA2CA1CA4CA12CA3 | |
| SCHEMBL9327446 | 0.69 | CA2 (0.56) | CA2CA1CA4CA12CA3 | |
| SCHEMBL9738906 | 0.69 | CA2 (0.78) | CA2CA1CA4CA12CA3 | |
| SCHEMBL9738903 | 0.69 | CA2 (0.78) | CA2CA1CA4CA12CA3 | |
| SCHEMBL13435694 | 0.68 | CA2 (0.56) | CA2CA1CA4CA12CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091409-A | Useful in treatment of ocular hypertension and glaucoma | MERCK & CO., INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0457586-A1 | 4-alkylamino-6-(C3-5-hydrocarbyl)thieno [2,3-B] thiopyran-2-sulfonamide-7,7-dioxides | MERCK & CO. INC. (US) | 1991-11-21 | — | — | EP | disclosed |