Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 14/20 | 0.74 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.56 |
| ▸ | PRNP | P04156 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
| ▸ | PTGFR | P43088 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9503660 | 0.86 | DHODH (0.78) | DHODHRXFP1PRNPPPARGNR2E3 | |
| SCHEMBL8792419 | 0.85 | DHODH (1.00) | DHODH | |
| SCHEMBL8794237 | 0.85 | DHODH (0.74) | DHODH | |
| SCHEMBL8792384 | 0.85 | DHODH (0.72) | DHODHPTGFR | |
| SCHEMBL8792622 | 0.84 | DHODH (0.72) | DHODH | |
| SCHEMBL8794239 | 0.84 | DHODH (0.79) | DHODH | |
| SCHEMBL8793893 | 0.84 | DHODH (0.67) | DHODHAURKAKDRAURKB | |
| SCHEMBL18075840 | 0.83 | DHODH (0.78) | DHODHRXFP1PRNPPPARGNR2E3 | |
| SCHEMBL22919495 | 0.83 | LMNA (0.70) | DHODHRXFP1PRNPPPARGNR2E3 | |
| SCHEMBL17594085 | 0.82 | DHODH (0.64) | DHODHRXFP1PRNPPPARGNR2E3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0379145-B1 | Substituted quinolinecarboxylic acids | AMERICAN CYANAMID CO (US) | 1997-05-07 | — | — | EP | claimed |
| EP-0379145-A2 | Substituted quinolinecarboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1990-07-25 | — | — | EP | claimed |
| EP-0379145-B1 | Substituted quinolinecarboxylic acids | AMERICAN CYANAMID CO (US) | 1997-05-07 | — | — | EP | disclosed |
| US-4968702-A | ANTIARTHRITIC, INHIBITORS OF PROGRESSIVE JOINT DETERIORATION, IMMUNOSUPPRESSANT | AMERICAN CYANAMID COMPANY (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0379145-A2 | Substituted quinolinecarboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1990-07-25 | — | — | EP | disclosed |