Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 17/20 | 0.78 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.67 |
| ▸ | PTGFR | P43088 | 1/20 | 0.58 |
| ▸ | PRNP | P04156 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18075840 | 0.97 | DHODH (0.78) | DHODHPDE10APTGFRPRNPPPARG | |
| SCHEMBL9501990 | 0.93 | DHODH (0.84) | DHODHPDE10AAURKAKDRAURKB | |
| SCHEMBL10581403 | 0.89 | DHODH (0.70) | DHODHPDE10APTGFRAURKAKDR | |
| SCHEMBL10583026 | 0.89 | DHODH (0.78) | DHODHPDE10APTGFRAURKAKDR | |
| SCHEMBL10584241 | 0.88 | DHODH (0.76) | DHODHPDE10APTGFRAURKAKDR | |
| SCHEMBL10580471 | 0.88 | DHODH (0.76) | DHODHPDE10APTGFRAURKAKDR | |
| SCHEMBL10583075 | 0.88 | DHODH (1.00) | DHODHPDE10AAURKAKDRAURKB | |
| SCHEMBL8794348 | 0.86 | DHODH (0.74) | DHODHPTGFRPRNPPPARGRXFP1 | |
| SCHEMBL10582724 | 0.86 | DHODH (0.71) | DHODHAURKAKDRAURKB | |
| SCHEMBL9505280 | 0.86 | DHODH (0.81) | DHODHPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0305952-B1 | SUBSTITUTED 2-PHENYL-4-QUINOLINE-CARBOXYLIC ACIDS | AMERICAN CYANAMID COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |
| EP-0305952-A1 | Substituted 2-phenyl-4-quinoline-carboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1989-03-08 | — | — | EP | disclosed |