Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | CKS1B | P61024 | 2/20 | 0.46 |
| ▸ | SKP1 | P63208 | 2/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.46 |
| ▸ | DTYMK | P23919 | 1/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8925823 | 0.87 | ACHE (0.49) | POLBKITACHECKS1BSKP1 | |
| SCHEMBL3330474 | 0.87 | POLB (0.51) | POLBKITACHECKS1BSKP1 | |
| SCHEMBL31652137 | 0.85 | POLB (0.54) | POLBKITACHECKS1BSKP1 | |
| SCHEMBL28766136 | 0.84 | ACHE (0.47) | POLBKITACHECKS1BSKP1 | |
| SCHEMBL8793256 | 0.84 | POLB (0.48) | POLBKITACHECKS1BSKP1 | |
| SCHEMBL22587512 | 0.83 | POLB (0.52) | POLBKITACHECKS1BSKP1 | |
| SCHEMBL8921494 | 0.83 | POLB (0.47) | POLBKITACHECKS1BSKP1 | |
| SCHEMBL8793643 | 0.82 | POLB (0.54) | POLBKITACHECKS1BSKP1 | |
| SCHEMBL29741439 | 0.82 | POLB (0.54) | POLBKITACHECKS1BSKP1 | |
| SCHEMBL31652019 | 0.82 | POLB (0.55) | POLBKITACHECKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777649-A1 | N- 2-(PYRROLIDINYL-1)-1-PHENYLETHYL]ACETAMIDES AS KAPPA RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1997-06-11 | — | — | EP | disclosed |
| US-5599930-A | Substituted indoles as anti-AIDS pharmaceuticals | THE UPJOHN COMPANY (US) | 1997-02-04 | — | — | US | disclosed |
| EP-0594702-B1 | SUBSTITUTED INDOLES AS ANTI-AIDS PHARMACEUTICALS | UPJOHN CO (US) | 1997-01-29 | — | — | EP | disclosed |
| WO-1996006077-A1 | N-[2-(PYRROLIDINYL-1)-1-PHENYLETHYL]ACETAMIDES AS KAPPA RECEPTOR ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 1996-02-29 | — | — | WO | disclosed |
| WO-1993001181-A1 | SUBSTITUTED INDOLES AS ANTI-AIDS PHARMACEUTICALS | THE UPJOHN COMPANY (US) | 1993-01-21 | — | — | WO | disclosed |