Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | MB | P02144 | 1/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9031190 | 0.84 | ALDH1A1 (0.49) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL7264596 | 0.83 | KMT2A (0.54) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL1285464 | 0.81 | MAPT (0.46) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL8773869 | 0.81 | POLB (0.41) | LMNAALDH1A1KMT2AMEN1CA1 | |
| SCHEMBL7810225 | 0.81 | CA1 (0.45) | LMNAALDH1A1CYP3A4KMT2AMEN1 | |
| SCHEMBL10471341 | 0.79 | TTR (0.52) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL6025981 | 0.78 | BACE1 (0.43) | ALDH1A1KMT2AMEN1TSHRBACE1 | |
| SCHEMBL11611125 | 0.78 | ALDH1A1 (0.41) | LMNAALDH1A1CYP1A2KMT2AMEN1 | |
| SCHEMBL14221326 | 0.78 | BACE1 (0.38) | LMNAALDH1A1CYP1A2KMT2AMEN1 | |
| SCHEMBL9528503 | 0.78 | USP2 (0.45) | LMNAALDH1A1CYP1A2MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611003-B1 | Substituted phenyl sulfonamides as selective B3 agonists for the treatment of diabetes and obesity | MERCK & CO INC (US) | 1997-06-18 | — | — | EP | disclosed |
| US-5451677-A | Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity | MERCK & CO., INC. (US) | 1995-09-19 | — | — | US | disclosed |
| WO-1994018161-A1 | SUBSTITUTED PHENYL SULFONAMIDES AS SELECTIVE β3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY | MERCK & CO., INC. (US) | 1994-08-18 | — | — | WO | disclosed |
| EP-0611003-A1 | Substituted phenyl sulfonamides as selective B3 agonists for the treatment of diabetes and obesity | MERCK & CO. INC. (US) | 1994-08-17 | — | — | EP | disclosed |
| US-5288756-A | Pesticides, miticides, larvicides; nontoxic to warm blood animals | CIBA-GEIGY CORPORATION (US) | 1994-02-22 | — | — | US | disclosed |
| EP-0219460-B1 | BENZOYLPHENYL UREAS | CIBA-GEIGY AG (CH) | 1991-05-02 | — | — | EP | disclosed |
| EP-0219460-A2 | Benzoylphenyl ureas | CIBA-GEIGY AG (CH) | 1987-04-22 | — | — | EP | disclosed |