Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.64 |
| ▸ | CA1 | P00915 | 5/20 | 0.64 |
| ▸ | CA2 | P00918 | 5/20 | 0.64 |
| ▸ | CA9 | Q16790 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | AR | P10275 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17675706 | 0.83 | CA12 (0.67) | CA12CA1CA2CA9MAPT | |
| SCHEMBL20946387 | 0.81 | LMNA (0.58) | CA12CA1CA2LMNAALDH1A1 | |
| SCHEMBL17309069 | 0.79 | CA12 (0.66) | CA12CA1CA2CA9MAPT | |
| SCHEMBL7079519 | 0.79 | MEN1 (0.58) | MEN1MAPTKMT2ASMN1; SMN2PKM | |
| SCHEMBL13306489 | 0.79 | CA1 (0.66) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL24920672 | 0.79 | CA12 (0.67) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL21625809 | 0.79 | CA1 (0.76) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL25623328 | 0.78 | CA12 (0.62) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL7486439 | 0.77 | ITGB3 (0.60) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL4459617 | 0.77 | CA12 (0.65) | CA12CA1CA2CA9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611003-B1 | Substituted phenyl sulfonamides as selective B3 agonists for the treatment of diabetes and obesity | MERCK & CO INC (US) | 1997-06-18 | — | — | EP | disclosed |
| US-5451677-A | Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity | MERCK & CO., INC. (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0611003-A1 | Substituted phenyl sulfonamides as selective B3 agonists for the treatment of diabetes and obesity | MERCK & CO. INC. (US) | 1994-08-17 | — | — | EP | disclosed |