Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.41 |
| ▸ | EGFR | P00533 | 5/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 4/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796483 | 0.95 | PDGFRB (0.45) | PDGFRBMEN1KMT2ARPS6KB1EGFR | |
| SCHEMBL8796096 | 0.94 | RPS6KB1 (0.46) | PDGFRBMEN1KMT2ARPS6KB1EGFR | |
| SCHEMBL8796525 | 0.94 | PDGFRB (0.46) | PDGFRBMEN1KMT2ARPS6KB1EGFR | |
| SCHEMBL8795890 | 0.93 | PIK3CA (0.47) | PDGFRBMEN1KMT2ARPS6KB1EGFR | |
| SCHEMBL8796031 | 0.92 | AURKA (0.48) | PDGFRBMEN1KMT2ARPS6KB1EGFR | |
| SCHEMBL8827440 | 0.91 | PDGFRB (0.44) | PDGFRBMEN1KMT2ARPS6KB1EGFR | |
| SCHEMBL8795496 | 0.88 | AURKA (0.49) | PDGFRBRPS6KB1EGFRAURKAAURKB | |
| SCHEMBL8795542 | 0.87 | AURKA (0.47) | PDGFRBRPS6KB1EGFRAURKAAURKB | |
| SCHEMBL8796500 | 0.85 | MEN1 (0.46) | PDGFRBMEN1KMT2AEGFRERBB2 | |
| SCHEMBL8796055 | 0.85 | RPS6KB1 (0.47) | PDGFRBMEN1KMT2ARPS6KB1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698560-A | TREATMENT OF CARDIOVASCULAR DISORDERS; ANTICOAGULANTS; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS; ARTERIOSCLEROSIS; CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0591333-B1 | AZANORBORNANE DERIVATIVES | PFIZER (US) | 1997-03-05 | — | — | EP | disclosed |
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |
| US-5604252-A | Azanorbornane derivatives | PFIZER INC. (US) | 1997-02-18 | — | — | US | disclosed |
| EP-0591333-A1 | AZANORBORNANE DERIVATIVES. | PFIZER (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993000330-A2 | AZANORBORNANE DERIVATIVES | PFIZER INC. (US) | 1993-01-07 | — | — | WO | disclosed |