Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 9/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8795332 | 0.90 | HTT (0.48) | MEN1KMT2APDGFRBEGFRHTT | |
| SCHEMBL8796525 | 0.89 | PDGFRB (0.46) | MEN1KMT2APDGFRBEGFRKDM4E | |
| SCHEMBL8825753 | 0.89 | MEN1 (0.60) | MEN1KMT2AEGFRHTTKDM4E | |
| SCHEMBL8795709 | 0.88 | EGFR (0.49) | MEN1KMT2APDGFRBEGFRERBB2 | |
| SCHEMBL8795881 | 0.88 | MEN1 (0.44) | MEN1KMT2APDGFRBEGFRERBB2 | |
| SCHEMBL8795099 | 0.88 | MEN1 (0.44) | MEN1KMT2APDGFRBEGFRERBB2 | |
| SCHEMBL8795310 | 0.88 | AURKA (0.44) | MEN1KMT2APDGFRBEGFRERBB2 | |
| SCHEMBL8796051 | 0.87 | MEN1 (0.43) | MEN1KMT2APDGFRBEGFRERBB2 | |
| SCHEMBL8796096 | 0.86 | RPS6KB1 (0.46) | MEN1KMT2APDGFRBEGFRHTT | |
| SCHEMBL7520792 | 0.86 | EGFR (0.45) | MEN1KMT2APDGFRBEGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698560-A | TREATMENT OF CARDIOVASCULAR DISORDERS; ANTICOAGULANTS; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS; ARTERIOSCLEROSIS; CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |