Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | SRC | P12931 | 4/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8795542 | 0.98 | AURKA (0.47) | AURKAAURKBRPS6KB1EGFRSRC | |
| SCHEMBL8796031 | 0.96 | AURKA (0.48) | AURKAAURKBRPS6KB1EGFRSRC | |
| SCHEMBL8796911 | 0.92 | AURKA (0.52) | AURKAAURKBRPS6KB1EGFRSRC | |
| SCHEMBL8796096 | 0.89 | RPS6KB1 (0.46) | AURKARPS6KB1EGFRKDM4EALDH1A1 | |
| SCHEMBL8795306 | 0.88 | PDGFRB (0.45) | AURKAAURKBRPS6KB1EGFRPDPK1 | |
| SCHEMBL8795890 | 0.88 | PIK3CA (0.47) | AURKAAURKBRPS6KB1EGFRKDM4E | |
| SCHEMBL8796483 | 0.88 | PDGFRB (0.45) | AURKAAURKBRPS6KB1EGFRPDGFRB | |
| SCHEMBL8796603 | 0.88 | LMNA (0.44) | EGFRKDM4EALDH1A1PDGFRB | |
| SCHEMBL8796103 | 0.88 | AURKA (0.56) | AURKAAURKBRPS6KB1EGFRSRC | |
| SCHEMBL8796525 | 0.87 | PDGFRB (0.46) | AURKAAURKBRPS6KB1EGFRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698560-A | TREATMENT OF CARDIOVASCULAR DISORDERS; ANTICOAGULANTS; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS; ARTERIOSCLEROSIS; CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |