Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8139679 | 0.85 | ALDH1A1 (0.44) | ALDH1A1MAPTKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL21893783 | 0.85 | APP (0.43) | ALDH1A1MAPTKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL20984757 | 0.84 | GAA (0.52) | ALDH1A1MAPTKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL25930778 | 0.83 | ALDH1A1 (0.42) | ALDH1A1MAPTKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL11415861 | 0.83 | JAK2 (0.43) | ALDH1A1MAPTKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL20984162 | 0.82 | JAK2 (0.43) | ALDH1A1MAPTKDM4EKMT2ASMN1; SMN2 | |
| Bromide SCHEMBL20984941 | 0.82 | ALDH1A1 (0.41) | ALDH1A1MAPTKDM4EKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL20984506 | 0.82 | ALDH1A1 (0.42) | ALDH1A1MAPTKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL3790244 | 0.81 | CA1 (0.58) | ALDH1A1MAPTKDM4ESMN1; SMN2CA12 | |
| SCHEMBL11499021 | 0.77 | KMT2A (0.50) | ALDH1A1MAPTKDM4EKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652239-A | TREATMENT OF STROKES, ISCHEMIC ATTACK, ANTAGONISTS OF EXCITATORY AMINO ACIDS GLUTAMATE AND ASPARTATE | IMPERIAL CHEMICAL COMPANY (GB) | 1997-07-29 | — | — | US | disclosed |
| EP-0512817-B1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LTD (GB) | 1997-02-19 | — | — | EP | disclosed |
| EP-0512817-A1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LIMITED (GB) | 1992-11-11 | — | — | EP | disclosed |