Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3296125 | 0.92 | DRD2 (0.68) | DRD2DRD1DRD3ALDH1A1HRH1 | |
| SCHEMBL113497 | 0.83 | HRH1 (0.67) | DRD2DRD1HRH1HTR1B | |
| SCHEMBL2571240 | 0.82 | ALDH1A1 (0.45) | DRD2DRD1DRD3ALDH1A1KDM4E | |
| SCHEMBL2903622 | 0.81 | CYP1A2 (0.61) | ALDH1A1HRH1KDM4ECHRM2MAPT | |
| SCHEMBL12408539 | 0.80 | KDM4E (0.52) | DRD2DRD1HRH1HTR1BKDM4E | |
| SCHEMBL11264924 | 0.80 | DRD2 (0.65) | DRD2DRD1DRD3ALDH1A1HRH1 | |
| SCHEMBL11600148 | 0.80 | ALDH1A1 (0.68) | DRD2DRD1DRD3ALDH1A1HTR1D | |
| SCHEMBL2911943 | 0.79 | MAPT (0.52) | DRD2DRD1DRD3KDM4EMAPT | |
| SCHEMBL9273006 | 0.79 | DRD2 (0.56) | DRD2DRD1DRD3ALDH1A1HRH1 | |
| SCHEMBL11260326 | 0.78 | ALDH1A1 (0.61) | DRD2DRD1DRD3ALDH1A1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |