Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | KCNN4 | O15554 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796508 | 0.88 | NPSR1 (0.42) | POLBLMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL8796091 | 0.85 | ALDH1A1 (0.40) | POLBLMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL8795835 | 0.85 | KMT2A (0.39) | KCNN4LMNASMN1; SMN2TDP1MAPT | |
| SCHEMBL8796326 | 0.84 | SMN1; SMN2 (0.46) | POLBKCNN4SMN1; SMN2MAPTMEN1 | |
| SCHEMBL17420423 | 0.74 | POLB (0.51) | POLBKCNN4LMNASMN1; SMN2TDP1 | |
| SCHEMBL1508218 | 0.74 | KCNN4 (0.47) | KCNN4LMNAMEN1GAAKMT2A | |
| SCHEMBL5004403 | 0.73 | POLB (0.47) | POLBKCNN4LMNASMN1; SMN2TDP1 | |
| SCHEMBL11578597 | 0.72 | SMN1; SMN2 (0.49) | POLBSMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL19797979 | 0.71 | KCNN4 (0.46) | POLBKCNN4LMNASMN1; SMN2TDP1 | |
| SCHEMBL29145552 | 0.70 | POLB (0.47) | POLBKCNN4LMNASMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629604-B1 | Alicyclic phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5436369-A | Alicyclic phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0629604-A2 | Alicyclic phospholipase A2 inhibitors | Bristol-Myers Company (US) | 1994-12-21 | — | — | EP | disclosed |