Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 5/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5158911 | 0.83 | MTNR1A (0.44) | ECE1PIN1TSHRNPSR1CYP11B2 | |
| SCHEMBL31072340 | 0.83 | MTNR1A (0.44) | ECE1PIN1TSHRNPSR1CYP11B2 | |
| SCHEMBL5880882 | 0.82 | KCNQ2 (0.38) | ECE1PIN1 | |
| SCHEMBL5965470 | 0.80 | IDO1 (0.42) | ECE1PIN1TSHRNPSR1CYP11B2 | |
| SCHEMBL31609333 | 0.80 | IDO1 (0.42) | ECE1PIN1TSHRNPSR1CYP11B2 | |
| SCHEMBL255287 | 0.80 | IDO1 (0.42) | ECE1PIN1TSHRNPSR1CYP11B2 | |
| SCHEMBL11733442 | 0.80 | PPARG (0.45) | PIN1TSHRNPSR1ACECYP11B2 | |
| SCHEMBL30481743 | 0.80 | IDO1 (0.42) | ECE1PIN1TSHRNPSR1CYP11B2 | |
| SCHEMBL11732922 | 0.78 | PIN1 (0.40) | ECE1PIN1TSHRNPSR1CYP11B2 | |
| SCHEMBL29496822 | 0.78 | PIN1 (0.40) | ECE1PIN1TSHRNPSR1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723442-A4 | LACTONE COMPOUNDS FOR TREATING PATIENTS WITH PRECANCEROUS LESIONS | CELL PATHWAYS INC (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0723442-A1 | LACTONE COMPOUNDS FOR TREATING PATIENTS WITH PRECANCEROUS LESIONS | CELL PATHWAYS, INC. (US) | 1996-07-31 | — | — | EP | disclosed |
| WO-1996003987-A1 | LACTONE COMPOUNDS FOR TREATING PATIENTS WITH PRECANCEROUS LESIONS | CELL PATHWAYS, INC. (US) | 1996-02-15 | — | — | WO | disclosed |