Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 4/20 | 0.44 |
| ▸ | KDR | P35968 | 7/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796533 | 0.96 | PIK3CA (0.45) | PIK3CAPDGFRBMAPK1EGFRKDR | |
| SCHEMBL8795731 | 0.95 | PIK3CA (0.45) | PIK3CAPDGFRBMAPK1EGFRKDR | |
| SCHEMBL8796494 | 0.94 | MAPK1 (0.44) | PDGFRBMAPK1EGFRKDRALDH1A1 | |
| SCHEMBL8796285 | 0.92 | SRC (0.47) | PDGFRBMAPK1EGFRKDREPHA2 | |
| SCHEMBL8795326 | 0.88 | SRC (0.52) | EGFRKDRKDM4E | |
| SCHEMBL8796374 | 0.88 | SRC (0.49) | EGFRKDRKDM4EFGFR1FLT1 | |
| SCHEMBL8796375 | 0.88 | EGFR (0.48) | PIK3CAPDGFRBMAPK1EGFRALDH1A1 | |
| SCHEMBL8795810 | 0.87 | EGFR (0.49) | PIK3CAPDGFRBMAPK1EGFRALDH1A1 | |
| SCHEMBL8795418 | 0.86 | MAPK1 (0.49) | PDGFRBMAPK1EGFRALDH1A1LMNA | |
| SCHEMBL8795890 | 0.85 | PIK3CA (0.47) | PIK3CAPDGFRBEGFRLTA4HPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698560-A | TREATMENT OF CARDIOVASCULAR DISORDERS; ANTICOAGULANTS; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS; ARTERIOSCLEROSIS; CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |