Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 8/20 | 0.49 |
| ▸ | EGFR | P00533 | 6/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8795326 | 0.98 | SRC (0.52) | SRCEGFRCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL8796285 | 0.95 | SRC (0.47) | SRCEGFRCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL8795731 | 0.92 | PIK3CA (0.45) | SRCEGFRCYP2D6CYP2C19KDR | |
| SCHEMBL8796533 | 0.90 | PIK3CA (0.45) | SRCEGFRCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL8070330 | 0.88 | ALDH1A1 (0.49) | SRCEGFRCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL8796494 | 0.88 | MAPK1 (0.44) | EGFRKDRKDM4EFGFR1FLT1 | |
| SCHEMBL8796269 | 0.88 | PIK3CA (0.46) | EGFRKDRKDM4EFGFR1FLT1 | |
| SCHEMBL8796308 | 0.87 | EGFR (0.47) | EGFRCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL8795542 | 0.86 | AURKA (0.47) | SRCEGFRKDRKDM4E | |
| SCHEMBL7519162 | 0.86 | CYP1A2 (0.47) | EGFRCYP1A2CYP2D6CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698560-A | TREATMENT OF CARDIOVASCULAR DISORDERS; ANTICOAGULANTS; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS; ARTERIOSCLEROSIS; CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |