Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.41 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.41 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.41 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.41 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8795810 | 0.99 | EGFR (0.49) | EGFRPDGFRBPIK3CAMAPTCACNB4 | |
| SCHEMBL8796008 | 0.93 | EGFR (0.48) | EGFRPDGFRBMAPK1HTTKDM4E | |
| SCHEMBL8795620 | 0.92 | EGFR (0.45) | EGFRPDGFRBPIK3CAMAPTMAPK1 | |
| SCHEMBL8796323 | 0.92 | EGFR (0.48) | EGFRPDGFRBPIK3CAMAPK1HTT | |
| SCHEMBL8796308 | 0.91 | EGFR (0.47) | EGFRPDGFRBMAPTMAPK1KDM4E | |
| SCHEMBL8796541 | 0.91 | EGFR (0.47) | EGFRPDGFRBMAPTMAPK1HTT | |
| SCHEMBL8796409 | 0.90 | PDGFRB (0.49) | EGFRPDGFRBMAPTMAPK1HTT | |
| SCHEMBL7530560 | 0.89 | EGFR (0.48) | EGFRPDGFRBPIK3CAMAPTMAPK1 | |
| SCHEMBL7526254 | 0.89 | EGFR (0.48) | EGFRPDGFRBPIK3CAMAPTMAPK1 | |
| SCHEMBL7527697 | 0.89 | EGFR (0.48) | EGFRPDGFRBPIK3CAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698560-A | TREATMENT OF CARDIOVASCULAR DISORDERS; ANTICOAGULANTS; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS; ARTERIOSCLEROSIS; CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |