Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 6/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 4/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796500 | 0.90 | MEN1 (0.46) | HTTPDGFRBEGFRMAPK1MEN1 | |
| SCHEMBL8825746 | 0.89 | HTT (0.62) | HTTEGFRMAPK1SMN1; SMN2AURKA | |
| SCHEMBL8796312 | 0.89 | AURKA (0.49) | HTTPDGFRBEGFRMAPK1SMN1; SMN2 | |
| SCHEMBL8795923 | 0.89 | HTT (0.46) | HTTPDGFRBEGFRMAPK1SMN1; SMN2 | |
| SCHEMBL8795456 | 0.88 | HTT (0.46) | HTTPDGFRBEGFRMAPK1SMN1; SMN2 | |
| SCHEMBL8795595 | 0.87 | EGFR (0.49) | HTTPDGFRBEGFRMAPK1CLK4 | |
| SCHEMBL8796055 | 0.86 | RPS6KB1 (0.47) | HTTPDGFRBEGFRMAPK1SMN1; SMN2 | |
| SCHEMBL8796103 | 0.85 | AURKA (0.56) | HTTPDGFRBEGFRMAPK1SMN1; SMN2 | |
| SCHEMBL8796911 | 0.84 | AURKA (0.52) | PDGFRBEGFRAURKARPS6KB1AURKB | |
| SCHEMBL8825839 | 0.84 | EGFR (0.62) | HTTEGFRMAPK1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698560-A | TREATMENT OF CARDIOVASCULAR DISORDERS; ANTICOAGULANTS; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS; ARTERIOSCLEROSIS; CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |