Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.45 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797216 | 0.88 | PTGS2 (0.55) | PTGS2CYP3A4CYP2C19CYP2A6CYP2B6 | |
| SCHEMBL693906 | 0.76 | CYP2A6 (0.59) | PTGS2CYP3A4CYP2C19CYP2A6CYP2B6 | |
| SCHEMBL7163500 | 0.74 | PTGS1 (0.58) | PTGS2CYP3A4CYP2C19CYP2A6CYP2B6 | |
| SCHEMBL7844988 | 0.74 | PTGS2 (0.52) | PTGS2KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL8188473 | 0.73 | ALDH1A1 (0.61) | PTGS2ALDH1A1CDK4MAPK14HPGD | |
| SCHEMBL7833390 | 0.73 | PTGS2 (0.62) | PTGS2KDM4EPTGS1MAPK14MAPT | |
| SCHEMBL7844983 | 0.73 | PTGS2 (0.62) | PTGS2KDM4EPTGS1MAPK14MAPT | |
| SCHEMBL4552990 | 0.71 | KDM4E (0.67) | CYP3A4CYP2C19KDM4EMEN1ALDH1A1 | |
| SCHEMBL3242265 | 0.71 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL213779 | 0.71 | PTGS2 (1.00) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |