Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797675 | 0.87 | HTT (0.43) | TP53HTTTBXA2RTHRBMAPT | |
| SCHEMBL8797665 | 0.81 | TBXA2R (0.38) | TDP1RAB9ATBXA2RMAPTMAPK1 | |
| SCHEMBL8797278 | 0.78 | TP53 (0.41) | TP53POLBTDP1RAB9AHTT | |
| SCHEMBL8797849 | 0.78 | TP53 (0.44) | TP53POLBTDP1RAB9AHTT | |
| SCHEMBL8798200 | 0.77 | TP53 (0.48) | TP53POLBTDP1RAB9AHTT | |
| SCHEMBL8797149 | 0.76 | HTT (0.41) | TP53POLBTDP1RAB9AHTT | |
| SCHEMBL8797662 | 0.74 | LPAR1 (0.46) | TP53TDP1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8797142 | 0.74 | HTT (0.42) | TP53POLBTDP1RAB9AHTT | |
| SCHEMBL8797482 | 0.73 | LPAR1 (0.45) | TP53POLBTDP1RAB9AMEN1 | |
| SCHEMBL8797886 | 0.72 | LPAR1 (0.42) | TP53TDP1KMT2ASMN1; SMN2TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |