Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797849 | 0.88 | TP53 (0.44) | HTTTP53POLBRAB9ATDP1 | |
| SCHEMBL8798268 | 0.88 | TP53 (0.46) | HTTTP53POLBTBXAS1 | |
| SCHEMBL8797675 | 0.87 | HTT (0.43) | HTTTP53 | |
| SCHEMBL8797055 | 0.84 | TP53 (0.38) | HTTTP53L3MBTL1POLBRAB9A | |
| SCHEMBL8797850 | 0.80 | KDM4E (0.42) | HTTTBXAS1 | |
| SCHEMBL8797272 | 0.80 | TP53 (0.45) | TP53 | |
| SCHEMBL8797368 | 0.80 | TP53 (0.38) | TP53TDP1TBXAS1 | |
| SCHEMBL8797451 | 0.79 | TP53 (0.39) | TP53POLBTDP1 | |
| SCHEMBL8797541 | 0.79 | LPAR1 (0.45) | TP53POLB | |
| SCHEMBL8797024 | 0.79 | GRM7 (0.41) | HTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |