Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797849 | 0.88 | TP53 (0.44) | HTTTBXA2RTP53MAPTTHRB | |
| SCHEMBL8797124 | 0.87 | TP53 (0.41) | HTTTBXA2RTP53MAPTTHRB | |
| SCHEMBL8797142 | 0.87 | HTT (0.42) | HTTTP53 | |
| SCHEMBL8797482 | 0.86 | LPAR1 (0.45) | TBXA2RTP53MAPTHDAC4HDAC7 | |
| SCHEMBL8797523 | 0.85 | MAPT (0.41) | HTTTBXA2RTP53MAPTHDAC4 | |
| SCHEMBL8797662 | 0.81 | LPAR1 (0.46) | TBXA2RTP53CCR1 | |
| SCHEMBL8797278 | 0.81 | TP53 (0.41) | HTTTP53MAPT | |
| SCHEMBL8797449 | 0.79 | LPAR1 (0.44) | HTTTBXA2RTP53MAPTHDAC4 | |
| SCHEMBL8798200 | 0.79 | TP53 (0.48) | HTTTP53MAPT | |
| SCHEMBL8797883 | 0.79 | LPAR1 (0.46) | HTTTBXA2RTP53MAPTHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |