Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.50 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.50 |
| ▸ | ALB | P02768 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.50 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.49 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.49 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLG | P54098 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10421043 | 1.00 | LMNA (0.50) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL8541689 | 1.00 | LMNA (0.50) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL8541693 | 1.00 | LMNA (0.50) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL8797151 | 1.00 | LMNA (0.50) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL9471195 | 1.00 | LMNA (0.50) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL9311419 | 0.89 | LMNA (0.54) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL9309775 | 0.88 | PDE3A (0.52) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL9471029 | 0.86 | LMNA (0.55) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL10468438 | 0.86 | LMNA (0.55) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL10518727 | 0.86 | LMNA (0.55) | LMNAPDE3ACACNA1FALBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0335355-B1 | Bis-(hydroxymethyl) cyclobutyl purines and pyrimidines | SQUIBB & SONS INC (US) | 1997-10-01 | — | — | EP | claimed |
| EP-0366059-A2 | Carbocyclic nucleoside analogs | BRISTOL-MYERS SQUIBB COMPANY (US) | 1990-05-02 | — | — | EP | claimed |
| EP-0335355-A2 | Bis-(hydroxymethyl) cyclobutyl purines and pyrimidines | E.R. Squibb & Sons, Inc. (US) | 1989-10-04 | — | — | EP | claimed |
| EP-0335355-B1 | Bis-(hydroxymethyl) cyclobutyl purines and pyrimidines | SQUIBB & SONS INC (US) | 1997-10-01 | — | — | EP | disclosed |
| US-5246931-A | Triazine-substituted cyclobutane derivatives; viricides; side effect reduction | BRISTOL-MYERS SQUIBB COMPANY (US) | 1993-09-21 | — | — | US | disclosed |
| US-5153352-A | Viricides and antitumor agent | BRISTOL-MYERS SQUIBB COMPANY (US) | 1992-10-06 | — | — | US | disclosed |
| US-5130462-A | Intermediates for viricides | E. R. SQUIBB & SONS, INC. (US) | 1992-07-14 | — | — | US | disclosed |
| US-5126345-A | Viricides | E. R. SQUIBB & SONS, INC. (US) | 1992-06-30 | — | — | US | disclosed |
| EP-0366059-A2 | Carbocyclic nucleoside analogs | BRISTOL-MYERS SQUIBB COMPANY (US) | 1990-05-02 | — | — | EP | disclosed |
| EP-0358154-A2 | Novel cyclobutane derivative and process for producing same | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1990-03-14 | — | — | EP | disclosed |
| EP-0335355-A2 | Bis-(hydroxymethyl) cyclobutyl purines and pyrimidines | E.R. Squibb & Sons, Inc. (US) | 1989-10-04 | — | — | EP | disclosed |