Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HRH1 | P35367 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797430 | 0.91 | ALDH1A1 (0.37) | HDAC4HDAC7HDAC5TBXA2RTBXAS1 | |
| SCHEMBL8797512 | 0.80 | ALDH1A1 (0.37) | HDAC4HDAC7HDAC5TBXA2RRAB9A | |
| SCHEMBL8797219 | 0.80 | TP53 (0.41) | HDAC4HDAC7HDAC5TBXA2RTBXAS1 | |
| SCHEMBL8797868 | 0.79 | KMT2A (0.40) | TP53HTTNPSR1 | |
| SCHEMBL10446931 | 0.78 | HTR2A (0.35) | HTR2AHTR2CHRH1 | |
| SCHEMBL19334942 | 0.78 | HTR2A (0.35) | HTR2AHTR2CHRH1 | |
| SCHEMBL8797149 | 0.78 | HTT (0.41) | RAB9ATP53HTT | |
| SCHEMBL8797337 | 0.76 | ALDH1A1 (0.42) | HDAC4HDAC7HDAC5TBXA2RTBXAS1 | |
| SCHEMBL8797301 | 0.76 | TBXA2R (0.39) | HDAC4HDAC7HDAC5TBXA2RTBXAS1 | |
| SCHEMBL10444651 | 0.74 | HTR2A (0.38) | HTR2AHTR2CHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |