Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 5/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797377 | 0.84 | TBXA2R (0.44) | TBXA2RTBXAS1GAA | |
| SCHEMBL5756742 | 0.82 | ATM (0.43) | TBXA2RTBXAS1HDAC4HDAC7HDAC5 | |
| SCHEMBL5756737 | 0.82 | ATM (0.43) | TBXA2RTBXAS1HDAC4HDAC7HDAC5 | |
| SCHEMBL8797219 | 0.81 | TP53 (0.41) | TBXA2RTBXAS1AKR1B1HDAC4HDAC7 | |
| SCHEMBL8797337 | 0.80 | ALDH1A1 (0.42) | TBXA2RTBXAS1AKR1B1HDAC4HDAC7 | |
| SCHEMBL8797894 | 0.79 | TBXA2R (0.40) | TBXA2RTBXAS1 | |
| SCHEMBL8797275 | 0.79 | MAOB (0.44) | TBXA2RTBXAS1MAOBNOTUM | |
| SCHEMBL8797251 | 0.79 | NOTUM (0.43) | TBXA2RTBXAS1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL6938853 | 0.79 | TBXA2R (0.45) | TBXA2RTBXAS1HDAC4HDAC7HDAC5 | |
| SCHEMBL8797519 | 0.79 | EDNRB (0.40) | TBXA2RTBXAS1AKR1B1HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |