Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4113696 | 0.86 | MEN1 (0.55) | TBXAS1KMT2AMEN1EGFRSRC | |
| SCHEMBL8797777 | 0.86 | TP53 (0.52) | TBXAS1KMT2ATP53TBXA2RLMNA | |
| SCHEMBL8798069 | 0.86 | TP53 (0.61) | TBXAS1KMT2ATP53TBXA2RALDH1A1 | |
| SCHEMBL8797377 | 0.85 | TBXA2R (0.44) | TBXAS1KMT2AMEN1TBXA2RGAA | |
| SCHEMBL8797272 | 0.84 | TP53 (0.45) | KMT2ATP53TBXA2RLMNASMN1; SMN2 | |
| SCHEMBL8798872 | 0.84 | TP53 (0.45) | TBXAS1KMT2ATP53NPC1RAB9A | |
| SCHEMBL8798337 | 0.84 | TP53 (0.45) | KMT2ATP53TBXA2RALDH1A1MAPT | |
| SCHEMBL8797849 | 0.83 | TP53 (0.44) | KMT2ATP53RAB9ATBXA2RMAPT | |
| SCHEMBL8798008 | 0.82 | LPAR1 (0.46) | TP53ALDH1A1LMNA | |
| SCHEMBL8798003 | 0.82 | TP53 (0.45) | KMT2AEGFRSRCTP53TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |