Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | XIAP | P98170 | 2/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798003 | 0.95 | TP53 (0.45) | TP53KMT2ATBXA2RALDH1A1HTT | |
| SCHEMBL8797777 | 0.89 | TP53 (0.52) | TP53KMT2ATBXA2RMAPTNPSR1 | |
| SCHEMBL8797523 | 0.87 | MAPT (0.41) | TP53KMT2AXIAPTBXA2RMAPT | |
| SCHEMBL8797272 | 0.87 | TP53 (0.45) | TP53KMT2ATBXA2RMAPTNPSR1 | |
| SCHEMBL8798872 | 0.87 | TP53 (0.45) | TP53KMT2ATBXA2RMAPTNPSR1 | |
| SCHEMBL8798069 | 0.87 | TP53 (0.61) | TP53KMT2ATBXA2RMAPTNPSR1 | |
| SCHEMBL8797531 | 0.86 | TP53 (0.38) | TP53XIAPTBXA2RMAPTNPSR1 | |
| SCHEMBL8797849 | 0.86 | TP53 (0.44) | TP53KMT2ATBXA2RMAPTNPSR1 | |
| SCHEMBL8797274 | 0.84 | TBXAS1 (0.45) | TP53KMT2ATBXA2RMAPTNPSR1 | |
| SCHEMBL8797123 | 0.81 | TP53 (0.40) | TP53KMT2AXIAPTBXA2RMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |