Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CTSS | P25774 | 4/20 | 0.43 |
| ▸ | CTSL | P07711 | 3/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797362 | 1.00 | POLB (0.44) | POLBCTSSCTSLCTSBALDH1A1 | |
| SCHEMBL8799283 | 0.84 | MEN1 (0.50) | CTSSCTSLCTSBALDH1A1NPSR1 | |
| SCHEMBL8798489 | 0.84 | MEN1 (0.50) | CTSSCTSLCTSBALDH1A1NPSR1 | |
| SCHEMBL8797734 | 0.82 | POLB (0.42) | POLBCTSSCTSLCTSBALDH1A1 | |
| SCHEMBL8797731 | 0.82 | POLB (0.42) | POLBCTSSCTSLCTSBALDH1A1 | |
| SCHEMBL8798861 | 0.81 | ALDH1A1 (0.42) | POLBALDH1A1NPSR1LMNAMEN1 | |
| SCHEMBL8798865 | 0.81 | ALDH1A1 (0.42) | POLBALDH1A1NPSR1LMNAMEN1 | |
| SCHEMBL8798241 | 0.75 | DPP4 (0.35) | LMNAMEN1KMT2A | |
| SCHEMBL8798108 | 0.75 | DPP4 (0.35) | LMNAMEN1KMT2A | |
| SCHEMBL1128948 | 0.74 | NPC1 (0.64) | ALDH1A1NPSR1KDM4ELMNAREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0687263-B1 | PROCESS FOR PREPARING (TRANS)-6- [2-(SUBSTITUTED-PYRROL-1-YL)ALKYL]PYRAN-2-ONE INHIBITORS OF CHOLESTEROL SYNTHESIS | WARNER LAMBERT CO (US) | 1997-07-30 | — | — | EP | claimed |
| EP-0687263-A1 | NOVEL PROCESS FOR -i(TRANS)-6- 2-(SUBSTITUTED-PYRROL-1-YL)ALKYL]PYRAN-2-ONE INHIBITORS OF CHOLESTEROL SYNTHESIS | WARNER LAMBERT CO (US) | 1995-12-20 | — | — | EP | claimed |
| WO-1994020492-A1 | NOVEL PROCESS FOR TRANS-6-[2-(SUBSTITUTED-PYRROL-1-YL)ALKYL]PYRAN-2-ONE INHIBITORS OF CHOLESTEROL SYNTHESIS | WARNER-LAMBERT COMPANY (US) | 1994-09-15 | — | — | WO | claimed |
| EP-0687263-B1 | PROCESS FOR PREPARING (TRANS)-6- [2-(SUBSTITUTED-PYRROL-1-YL)ALKYL]PYRAN-2-ONE INHIBITORS OF CHOLESTEROL SYNTHESIS | WARNER LAMBERT CO (US) | 1997-07-30 | — | — | EP | disclosed |
| US-5510488-A | Process for trans-6- 2-(substituted-pyrrol-1-yl)alkyl!pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1996-04-23 | — | — | US | disclosed |
| US-5489691-A | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |
| US-5489690-A | Process for trans-6[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |
| US-5470981-A | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1995-11-28 | — | — | US | disclosed |
| US-5446054-A | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1995-08-29 | — | — | US | disclosed |
| US-5397792-A | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1995-03-14 | — | — | US | disclosed |
| WO-1994020492-A1 | NOVEL PROCESS FOR TRANS-6-[2-(SUBSTITUTED-PYRROL-1-YL)ALKYL]PYRAN-2-ONE INHIBITORS OF CHOLESTEROL SYNTHESIS | WARNER-LAMBERT COMPANY (US) | 1994-09-15 | — | — | WO | disclosed |
| US-5342952-A | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1994-08-30 | — | — | US | disclosed |
| US-5298627-A | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1994-03-29 | — | — | US | disclosed |