Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.61 |
| ▸ | DRD4 | P21917 | 6/20 | 0.57 |
| ▸ | DRD2 | P14416 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | KDM4A | O75164 | 1/20 | 0.54 |
| ▸ | KDM4B | O94953 | 1/20 | 0.54 |
| ▸ | KDM5C | P41229 | 1/20 | 0.54 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797245 | 0.86 | POLB (0.62) | KMT2ADRD4DRD2ALDH1A1KDM4E | |
| SCHEMBL8798141 | 0.83 | KMT2A (0.48) | KMT2AMAPTCHIADRD4DRD2 | |
| SCHEMBL8797703 | 0.83 | MAPT (0.47) | KMT2AMAPTCHIADRD4DRD2 | |
| SCHEMBL8797666 | 0.81 | KDM4E (0.57) | KMT2AMAPTCHIADRD2ALDH1A1 | |
| SCHEMBL8627719 | 0.81 | DRD4 (0.58) | MAPTDRD4DRD2ALDH1A1KDM4E | |
| SCHEMBL8797340 | 0.80 | HTR3A (0.51) | KMT2AMAPTCHIADRD4DRD2 | |
| SCHEMBL8797561 | 0.80 | KMT2A (0.56) | KMT2AMAPTDRD4ALDH1A1KDM4E | |
| SCHEMBL8797637 | 0.80 | LMNA (0.45) | KMT2AMAPTCHIADRD4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9393795 | 0.79 | KMT2A (0.55) | KMT2AMAPTDRD4ALDH1A1KDM4E | |
| SCHEMBL6977832 | 0.79 | KDM4E (0.53) | KMT2AMAPTALDH1A1KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0689539-B1 | ANTIPSYCHOTIC INDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1997-12-03 | — | — | EP | claimed |
| EP-0689539-A1 | ANTIPSYCHOTIC INDAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1996-01-03 | — | — | EP | claimed |
| WO-1994021630-A1 | ANTIPSYCHOTIC INDAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-29 | — | — | WO | claimed |
| EP-0689539-B1 | ANTIPSYCHOTIC INDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1997-12-03 | — | — | EP | disclosed |
| EP-0689539-A1 | ANTIPSYCHOTIC INDAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1996-01-03 | — | — | EP | disclosed |
| WO-1994021630-A1 | ANTIPSYCHOTIC INDAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-29 | — | — | WO | disclosed |