Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 10/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8800082 | 0.90 | KMT2A (0.55) | LPAR1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL8797272 | 0.84 | TP53 (0.45) | LPAR1LMNAKMT2ANLRP3TP53 | |
| SCHEMBL8797711 | 0.83 | LPAR1 (0.49) | LPAR1LMNAKMT2ATP53SMN1; SMN2 | |
| SCHEMBL8797184 | 0.83 | LPAR1 (0.46) | LPAR1LMNAKMT2ANLRP3CYP3A4 | |
| SCHEMBL8797886 | 0.78 | LPAR1 (0.42) | LPAR1LMNAKMT2ANLRP3TP53 | |
| SCHEMBL8797371 | 0.76 | TP53 (0.42) | LPAR1LMNAKMT2ANLRP3TP53 | |
| SCHEMBL8797526 | 0.76 | TSHR (0.42) | LMNAKMT2A | |
| SCHEMBL8797783 | 0.76 | TP53 (0.40) | LPAR1KMT2ANLRP3TP53CYP3A4 | |
| SCHEMBL8797529 | 0.76 | TP53 (0.46) | LPAR1LMNAKMT2ANLRP3TP53 | |
| SCHEMBL8798008 | 0.76 | LPAR1 (0.46) | LPAR1LMNANLRP3TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | claimed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | claimed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | claimed |
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |