Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | ACP3 | P15309 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15224175 | 0.86 | ALDH1A1 (0.49) | LMNAOPRM1OPRK1ACP3CYP2D6 | |
| SCHEMBL3879203 | 0.85 | TSHR (0.53) | TSHRNPSR1OPRM1ACP3CYP2D6 | |
| Hydrochloric Acid SCHEMBL11492466 | 0.83 | TSHR (0.56) | TSHRNPSR1OPRM1ACP3CYP2D6 | |
| SCHEMBL20169172 | 0.81 | LMNA (0.44) | LMNAKMT2AMEN1 | |
| SCHEMBL22193827 | 0.80 | OPRM1 (0.44) | LMNAOPRM1OPRK1CYP2D6KMT2A | |
| SCHEMBL8797377 | 0.80 | TBXA2R (0.44) | TSHRCYP2D6KMT2AMEN1HTT | |
| SCHEMBL11837659 | 0.78 | PRCP (0.44) | LMNAOPRM1OPRK1ACP3CYP2D6 | |
| SCHEMBL8797481 | 0.76 | LPAR1 (0.47) | LMNAKMT2A | |
| SCHEMBL1161912 | 0.76 | TSHR (0.49) | TSHRNPSR1OPRM1ACP3CYP2D6 | |
| SCHEMBL9449539 | 0.76 | HDAC3 (0.44) | LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |