Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 15/20 | 0.78 |
| ▸ | EDNRA | P25101 | 6/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798379 | 0.93 | EDNRB (0.81) | EDNRBEDNRATP53MAPT | |
| SCHEMBL8578004 | 0.88 | EDNRB (0.86) | EDNRBEDNRA | |
| SCHEMBL795880 | 0.87 | EDNRB (1.00) | EDNRBEDNRA | |
| SCHEMBL8799108 | 0.83 | EDNRB (0.77) | EDNRBEDNRATP53MAPT | |
| SCHEMBL8798624 | 0.83 | EDNRB (0.63) | EDNRBEDNRAMAPT | |
| SCHEMBL8798255 | 0.82 | EDNRB (0.79) | EDNRBEDNRAMAPT | |
| SCHEMBL8798910 | 0.82 | EDNRB (0.73) | EDNRBTP53MAPT | |
| SCHEMBL8798670 | 0.81 | EDNRB (0.63) | EDNRBEDNRA | |
| SCHEMBL8798547 | 0.80 | EDNRB (0.56) | EDNRBEDNRA | |
| SCHEMBL8798525 | 0.80 | EDNRB (0.61) | EDNRBEDNRATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757039-A1 | Endothelin receptor antagonists | MERCK PATENT GmbH (DE) | 1997-02-05 | — | — | EP | disclosed |