Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 15/20 | 0.79 |
| ▸ | EDNRA | P25101 | 9/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798379 | 0.89 | EDNRB (0.81) | EDNRBEDNRAMAPT | |
| SCHEMBL6315635 | 0.88 | EDNRB (1.00) | EDNRBEDNRAALDH1A1KDM4E | |
| SCHEMBL8798950 | 0.88 | EDNRB (0.81) | EDNRBEDNRAALDH1A1HPGDMAPK1 | |
| SCHEMBL8798982 | 0.87 | EDNRB (0.78) | EDNRBEDNRA | |
| SCHEMBL8798028 | 0.86 | EDNRB (0.74) | EDNRBEDNRAMAPT | |
| SCHEMBL6314927 | 0.86 | EDNRB (0.79) | EDNRBEDNRAALDH1A1HPGDMAPK1 | |
| SCHEMBL8580902 | 0.83 | EDNRB (0.75) | EDNRBEDNRAALDH1A1HPGDMAPK1 | |
| SCHEMBL8797682 | 0.82 | EDNRB (0.78) | EDNRBEDNRAMAPT | |
| SCHEMBL8798300 | 0.81 | EDNRB (0.71) | EDNRBEDNRAALDH1A1KDM4EMAPT | |
| SCHEMBL8799703 | 0.81 | EDNRB (0.66) | EDNRBEDNRAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757039-A1 | Endothelin receptor antagonists | MERCK PATENT GmbH (DE) | 1997-02-05 | — | — | EP | claimed |