Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 8/20 | 0.34 |
| ▸ | HTR2C | P28335 | 8/20 | 0.34 |
| ▸ | HRH1 | P35367 | 3/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7520603 | 0.90 | DRD2 (0.39) | TBXA2RHTR2AHTR2CHRH1SLC6A2 | |
| SCHEMBL8799491 | 0.90 | TBXA2R (0.36) | TBXA2RHTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL7526416 | 0.85 | HTR2A (0.40) | HTR2AHTR2CHRH1 | |
| SCHEMBL8797971 | 0.83 | KDM4E (0.35) | TBXA2RHTR2AHTR2CSLC6A2HTR2B | |
| SCHEMBL9196224 | 0.81 | TDP1 (0.41) | HTR2AHTR2CSLC6A2SLC6A4HTR2B | |
| SCHEMBL11272135 | 0.75 | HTR2B (0.36) | HTR2AHTR2CHRH1SLC6A2SLC6A4 | |
| SCHEMBL9063943 | 0.75 | TBXA2R (0.41) | TBXA2RHTR2AHTR2CHRH1SLC6A2 | |
| SCHEMBL7509159 | 0.75 | TBXA2R (0.41) | TBXA2RHTR2AHTR2CHRH1SLC6A2 | |
| SCHEMBL8797713 | 0.74 | TBXA2R (0.44) | TBXA2RDRD2DRD3 | |
| SCHEMBL8797896 | 0.74 | DRD2 (0.33) | TBXA2RHTR2AHTR2CHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |