Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 18/20 | 0.64 |
| ▸ | EDNRA | P25101 | 14/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798670 | 0.94 | EDNRB (0.63) | EDNRBEDNRA | |
| SCHEMBL8798525 | 0.91 | EDNRB (0.61) | EDNRBEDNRA | |
| SCHEMBL8798775 | 0.89 | EDNRB (0.60) | EDNRBEDNRA | |
| SCHEMBL6321016 | 0.88 | EDNRB (0.77) | EDNRBEDNRA | |
| SCHEMBL8798379 | 0.87 | EDNRB (0.81) | EDNRBEDNRAMAPT | |
| SCHEMBL8798028 | 0.86 | EDNRB (0.74) | EDNRBEDNRAMAPT | |
| SCHEMBL8798982 | 0.83 | EDNRB (0.78) | EDNRBEDNRA | |
| SCHEMBL6312676 | 0.82 | EDNRB (0.80) | EDNRBEDNRA | |
| SCHEMBL8799703 | 0.80 | EDNRB (0.66) | EDNRBEDNRA | |
| SCHEMBL8797682 | 0.80 | EDNRB (0.78) | EDNRBEDNRAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757039-A1 | Endothelin receptor antagonists | MERCK PATENT GmbH (DE) | 1997-02-05 | — | — | EP | claimed |