Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 14/20 | 0.66 |
| ▸ | EDNRA | P25101 | 9/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798624 | 0.93 | EDNRB (0.63) | EDNRBEDNRAKMT2AKDM4EALDH1A1 | |
| SCHEMBL8578754 | 0.89 | EDNRB (0.83) | EDNRBEDNRAKDM4EALDH1A1 | |
| SCHEMBL8578633 | 0.87 | EDNRB (0.73) | EDNRBEDNRAKMT2A | |
| SCHEMBL8798655 | 0.85 | EDNRB (0.67) | EDNRBEDNRAKMT2AKDM4EALDH1A1 | |
| SCHEMBL8798670 | 0.83 | EDNRB (0.63) | EDNRBEDNRA | |
| SCHEMBL8798379 | 0.83 | EDNRB (0.81) | EDNRBEDNRA | |
| SCHEMBL8798982 | 0.82 | EDNRB (0.78) | EDNRBEDNRA | |
| SCHEMBL8798255 | 0.81 | EDNRB (0.79) | EDNRBEDNRAKDM4EALDH1A1 | |
| SCHEMBL8798525 | 0.81 | EDNRB (0.61) | EDNRBEDNRA | |
| SCHEMBL8798374 | 0.80 | EDNRB (0.64) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757039-A1 | Endothelin receptor antagonists | MERCK PATENT GmbH (DE) | 1997-02-05 | — | — | EP | disclosed |