Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798712 | 0.85 | MAPT (0.62) | ALDH1A1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL10562235 | 0.85 | MAPT (0.59) | ALDH1A1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9316823 | 0.82 | ALDH1A1 (0.58) | ALDH1A1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL10843103 | 0.80 | MAPT (0.59) | ALDH1A1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8798148 | 0.80 | ALDH1A1 (0.68) | ALDH1A1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL11003266 | 0.79 | MAPT (0.55) | ALDH1A1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL28346187 | 0.78 | ALDH1A1 (0.64) | ALDH1A1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL12701382 | 0.78 | MAOA (0.50) | ALDH1A1MAPTRAB9ANPC1GAA | |
| SCHEMBL29375440 | 0.77 | MAPT (0.67) | ALDH1A1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL86392 | 0.77 | MAPT (0.67) | ALDH1A1MAPTRAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |