SCHEMBL879843

SCHEMBL879843

C=CS(=O)(=O)N1CCC2(CC1)N=C(c1cccc(C(F)(F)F)c1)NC2=O

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 1/20 0.41
PTH1R Q03431 5/20 0.38
PRF1 P14222 1/20 0.38
PARP1 P09874 1/20 0.36
NPY5R Q15761 1/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
HTT P42858 1/20 0.36
GAA P10253 1/20 0.35
MAPT P10636 1/20 0.35
IDO1 P14902 1/20 0.35
DCTPP1 Q9H773 1/20 0.35
NOTUM Q6P988 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL848079 0.85 PTH1R (0.46) PTH1R
SCHEMBL16302311 0.85 PARP1 (0.39) PRF1PARP1NPY5RMEN1KMT2A
SCHEMBL16302288 0.83 PTH1R (0.40) PTH1R
SCHEMBL849398 0.82 PTH1R (0.38) PTH1R
SCHEMBL10290600 0.81 PARP1 (0.36) CHRNA7PRF1PARP1NPY5RMEN1
SCHEMBL16358550 0.81 PARP1 (0.36) CHRNA7PRF1PARP1NPY5RMEN1
SCHEMBL849742 0.80 KMT2A (0.46) MEN1KMT2AHTTGAAMAPT
SCHEMBL13551986 0.80 MEN1 (0.33) PTH1RNPY5RMEN1KMT2A
SCHEMBL13552134 0.80 PTH1R (0.39) CHRNA7PTH1RMEN1KMT2A
SCHEMBL849731 0.79 HSD11B1 (0.49) MEN1KMT2AHTTGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220162208-A1 HYDANTOIN DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2022-05-26 US disclosed
US-20220162208-A1 HYDANTOIN DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2022-05-26 US disclosed
US-20210024524-A1 HYDANTOIN DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2021-01-28 US disclosed
US-20210024524-A1 HYDANTOIN DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2021-01-28 US disclosed
US-20180237436-A1 HYDANTOIN DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2018-08-23 US disclosed
US-9993462-B2 Hydantoin derivative-containing pharmaceutical composition CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2018-06-12 US disclosed
US-9993462-B2 Hydantoin derivative-containing pharmaceutical composition CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2018-06-12 US disclosed
US-9993462-B2 Hydantoin derivative-containing pharmaceutical composition CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2018-06-12 US disclosed
EP-2930176-B1 HYDANTOIN DERIVATIVE CHUGAI PHARMACEUTICAL CO LTD (JP) 2018-02-07 EP disclosed
EP-2930176-B1 HYDANTOIN DERIVATIVE CHUGAI PHARMACEUTICAL CO LTD (JP) 2018-02-07 EP disclosed
EP-2930176-A1 HYDANTOIN DERIVATIVE Chugai Seiyaku Kabushiki Kaisha (JP) 2015-10-14 EP disclosed
EP-2930176-A1 HYDANTOIN DERIVATIVE Chugai Seiyaku Kabushiki Kaisha (JP) 2015-10-14 EP disclosed
US-20150274727-A1 HYDANTOIN DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2015-10-01 US disclosed
US-20150274727-A1 HYDANTOIN DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2015-10-01 US disclosed
US-20150274727-A1 HYDANTOIN DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2015-10-01 US disclosed
WO-2014092061-A1 HYDANTOIN DERIVATIVE 中外製薬株式会社 (JP) 2014-06-19 WO disclosed
US-20120270838-A1 SPIROIMIDAZOLONE DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2012-10-25 US disclosed
US-20120270838-A1 SPIROIMIDAZOLONE DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2012-10-25 US disclosed
EP-2433940-A1 SPIROIMIDAZOLONE DERIVATIVE Chugai Seiyaku Kabushiki Kaisha (JP) 2012-03-28 EP disclosed
WO-2010126030-A1 SPIROIMIDAZOLONE DERIVATIVE 中外製薬株式会社 (JP) 2010-11-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120270838-A1 SPIROIMIDAZOLONE DERIVATIVE WNK3, REN, SGK3 CHRNA7 2523/4885PTH1R 1869/4885PRF1 4552/4885
US-20210024524-A1 HYDANTOIN DERIVATIVE HRH4, HRH3, H1-3 CHRNA7 2638/4885PTH1R 2316/4885PRF1 2335/4885
US-20150274727-A1 HYDANTOIN DERIVATIVE HRH4, HRH3, H1-3 CHRNA7 2638/4885PTH1R 2316/4885PRF1 2335/4885
US-20180237436-A1 HYDANTOIN DERIVATIVE HRH4, HRH3, H1-3 CHRNA7 2638/4885PTH1R 2316/4885PRF1 2335/4885
US-20220162208-A1 HYDANTOIN DERIVATIVE HRH4, HRH3, H1-3 CHRNA7 2638/4885PTH1R 2316/4885PRF1 2335/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.