Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 3/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797377 | 0.83 | TBXA2R (0.44) | TBXAS1TBXA2RMAPT | |
| SCHEMBL7518917 | 0.82 | PARP1 (0.41) | TBXAS1TBXA2RPARP1HCRTR2POLB | |
| SCHEMBL5756742 | 0.80 | ATM (0.43) | TBXAS1TBXA2R | |
| SCHEMBL5756737 | 0.80 | ATM (0.43) | TBXAS1TBXA2R | |
| SCHEMBL6938853 | 0.80 | TBXA2R (0.45) | TBXAS1TBXA2R | |
| SCHEMBL8797894 | 0.80 | TBXA2R (0.40) | TBXAS1TBXA2R | |
| SCHEMBL8797055 | 0.80 | TP53 (0.38) | POLBMAPTTDP1 | |
| SCHEMBL8797251 | 0.80 | NOTUM (0.43) | TBXAS1TBXA2R | |
| SCHEMBL8797275 | 0.80 | MAOB (0.44) | TBXAS1TBXA2RPOLBMAPTTHRB | |
| SCHEMBL8797046 | 0.80 | TBXA2R (0.46) | TBXAS1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |