Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11116343 | 0.85 | PARP1 (0.41) | PARP1HTR2AHTR2CHRH1HCRTR2 | |
| SCHEMBL9749953 | 0.84 | TBXAS1 (0.37) | TBXAS1 | |
| SCHEMBL8798529 | 0.82 | TBXAS1 (0.41) | PARP1HCRTR2TBXAS1POLBMAPT | |
| SCHEMBL10565563 | 0.82 | AKR1B1 (0.57) | HRH1TBXAS1TBXA2R | |
| SCHEMBL7513748 | 0.80 | MAPT (0.43) | TBXAS1MAPTTBXA2R | |
| SCHEMBL11731964 | 0.80 | MAOA (0.61) | MAPT | |
| SCHEMBL7509154 | 0.80 | KMT2A (0.42) | HTR2AHTR2CHRH1MAPTTBXA2R | |
| SCHEMBL10923308 | 0.79 | PTPN1 (0.40) | TBXAS1POLBMAPTTDP1TBXA2R | |
| SCHEMBL11151324 | 0.78 | DRD2 (0.38) | PARP1 | |
| SCHEMBL9044716 | 0.78 | RAB9A (0.44) | TBXAS1MAPTTDP1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0974583-B1 | PHENYLPIPERIDINE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2002-05-29 | — | — | EP | disclosed |
| US-6150355-A | ANALGESICS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-11-21 | — | — | US | disclosed |
| EP-0974583-A1 | PHENYLPIPERIDINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-01-26 | — | — | EP | disclosed |
| US-4396550-A | ANTICHOLINERGIC, ANTIHISTIMINIC AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1983-08-02 | — | — | US | disclosed |
| EP-0038564-A1 | Dibenz (b,e) oxepin derivatives and pharmaceutical compositions comprising them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1981-10-28 | — | — | EP | disclosed |