Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | HTR1D | P28221 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798584 | 1.00 | HTR1A (0.56) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL8958128 | 0.99 | HTR1A (0.55) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL8957939 | 0.99 | HTR1A (0.55) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL8783796 | 0.87 | HTR1A (0.42) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL8784003 | 0.87 | HTR1A (0.42) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL8783793 | 0.87 | HTR1A (0.42) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL7937291 | 0.85 | HTR1A (0.62) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL8799021 | 0.77 | HTR1A (0.61) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL8796977 | 0.77 | HTR1A (0.61) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL8798496 | 0.76 | HTR1A (0.60) | HTR1AHTR1DHTR2BALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793663-A1 | (THIOPHEN-2-YL)-PIPERIDIN OR TETRAHYDROPYRIDIN CARBOXAMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-10 | — | — | EP | claimed |
| US-5525600-A | COMPOUND USEFUL AS ANTIPSYCHOTIC, ANTIDEPRESSANT AND ANXIBLYTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-06-11 | — | — | US | claimed |
| WO-1996016961-A1 | (THIOPHEN-2-YL)-PIPERIDIN OR TETRAHYDROPYRIDIN CARBOXAMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-06-06 | — | — | WO | claimed |
| EP-0793663-A1 | (THIOPHEN-2-YL)-PIPERIDIN OR TETRAHYDROPYRIDIN CARBOXAMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-10 | — | — | EP | disclosed |
| US-5525600-A | COMPOUND USEFUL AS ANTIPSYCHOTIC, ANTIDEPRESSANT AND ANXIBLYTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-06-11 | — | — | US | disclosed |
| WO-1996016961-A1 | (THIOPHEN-2-YL)-PIPERIDIN OR TETRAHYDROPYRIDIN CARBOXAMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-06-06 | — | — | WO | disclosed |